MINISTRY OF DEFENCE

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  MINISTRY OF DEFENCE. Establishment Of National University In Islamabad Total position. 29 Domicile , All over Pakistan    Qualification  intermediate to bachelor positions . Project Engineer(Civil) account Officer  supervisor assistant office boy     How to apply.   Apply online through the link https://www.fgei-cg.gov.pk/nup-rec.php   Last date to apply  02 April 2023. No TA/DA Fo Interview 
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Cytoskeleton,(Microtubules,Intermediate Filament,Microfilament

Cytoskeleton (Microtubules,Intermediate Filament,Microfilament


Cytoskeleton:
skeleton of cell maintain the structure of cell.
 permits the cell to change shape and move. Cytoskeleton composed of microtubules,microfilaments and intermediate filaments.

microtubules



Microtubule

they are long  unbranched and slender structure.

==> Road inside cell for transportation.

 Made up of two Globular protein,Alpha tubulin and  beta tubulin,they are involved in the formation and degeneration of spindle during cell division.
==> Several cell organelle are derived from microtubules,these organelles are cilia,flagella,basal bodies and Centriole.
==> They provide the tracks along with several different molecular moters move,transport vesicle, organelles such as secretary granules and mitochondria.
==> The anticancer paclitaxel  (taxol) binds to microtubules and make them so stable so that organelles can't move, mitotic spindle can't form and the cell die.
==> Constant assembly and disassembly.

Intermediate Filament

Provide support and strength to the cell as Steel rods in building which give strength and shape to building.
==> Connect the nuclear membrane to the cell membrane.
==> They maintain the shape of cell.
==> They are involved in integration of cell components
==> Form of flexible scaffolding for the cell and help it resist external pressure.
==> Absence of intermediate filament causes self rupture and when they are abnormal in human blistering
==> Support to hear
==> Nail,Skin,Hair and horn are made up of intermediate filament.

 microfilaments
==> 4 to 6 nm diameter that are made up of actin.
 ==> Actin is associated with muscle contraction.
==> It is present in all types of cell.
==> Actin is associated with muscle contraction.
==> It is present in all types of cell.

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